{"id":35408,"date":"2023-07-12T11:16:02","date_gmt":"2023-07-12T08:16:02","guid":{"rendered":"https:\/\/codental.uobaghdad.edu.iq\/?p=35408"},"modified":"2023-07-12T11:16:02","modified_gmt":"2023-07-12T08:16:02","slug":"%d8%a7%d8%b7%d8%b1%d9%88%d8%ad%d8%a9-%d9%81%d9%8a-%d9%83%d9%84%d9%8a%d8%a9-%d8%b7%d8%a8-%d8%a7%d9%84%d8%a3%d8%b3%d9%86%d8%a7%d9%86-%d8%aa%d8%a8%d8%ad%d8%ab-%d8%ad%d9%88%d9%84-%d8%aa%d9%82%d9%8a%d9%8a","status":"publish","type":"post","link":"https:\/\/codental.uobaghdad.edu.iq\/?p=35408","title":{"rendered":"\u0627\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u062a\u0628\u062d\u062b \u062d\u0648\u0644 \u062a\u0642\u064a\u064a\u0645 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648\u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0645\u0627 \u0628\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0644\u0639\u0627\u0628 Caspase-1 \u0648TNF-\u03b1"},"content":{"rendered":"

\u0627\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u062a\u0628\u062d\u062b \u062d\u0648\u0644 \u062a\u0642\u064a\u064a\u0645 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648\u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0645\u0627 \u0628\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0644\u0639\u0627\u0628 Caspase-1 \u0648TNF-\u03b1<\/span>
\n\u0646\u0627\u0642\u0634\u062a \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0627\u0633\u0646\u0627\u0646 \u0628\u062c\u0627\u0645\u0639\u0629 \u0628\u063a\u062f\u0627\u062f \u0627\u0637\u0631\u0648\u062d\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0627\u0644\u0645\u0648\u0633\u0648\u0645\u0629 (\u062a\u0642\u064a\u064a\u0645 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648\u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0645\u0627 \u0628\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0644\u0639\u0627\u0628 Caspase-1 \u0648TNF-\u03b1) \u0644\u0644\u0637\u0627\u0644\u0628\u0629 \u0639\u0630\u0631\u0627\u0621 \u0639\u0644\u064a \u0645\u062d\u0645\u0648\u062f.<\/span>
\n\u0647\u062f\u0641 \u0627\u0644\u0627\u0637\u0631\u0648\u062d\u0629 \u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0641\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0639\u0631\u0628 \u0627\u0644\u0639\u0631\u0627\u0642\u064a\u064a\u0646 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u0648\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0627 \u0628\u0627\u0644\u0639\u0644\u0627\u0645\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0644\u0639\u0627\u0628\u064a\u0629 caspase-1 \u0648 TNF-\u03b1.<\/span>
\n\u0648 \u062a\u0636\u0645\u062a \u0627\u0644\u0627\u0637\u0631\u0648\u062d\u0629 94 \u0634\u062e\u0635\u064b\u0627 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 30 \u0648 55 \u0639\u0627\u0645\u064b\u0627. \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629 (\u0646 = 32) \u0644\u062f\u064a\u0647\u0645 \u0644\u062b\u0629 \u0633\u0644\u064a\u0645\u0629 \u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062d\u0627\u0644\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 (\u0646 = 62). \u062a\u0645 \u062a\u0642\u062f\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0644\u0639\u0627\u0628\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0645\u062d\u0641\u0632\u0629 \u0645\u0646 Caspase-1 \u0648 TNF-\u03b1 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0642\u0627\u064a\u0633\u0629 \u0627\u0644\u0645\u0645\u062a\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0625\u0646\u0632\u064a\u0645 (ELISA) \u060c \u0648\u062a\u0645 \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0627\u0639\u0631\u0627\u0636 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u060c \u0648\u062a\u0645 \u062c\u0645\u0639 2 \u0645\u0644 \u0645\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0644\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0643\u0644 \u0641\u0631\u062f. \u0648 \u0643\u0634\u0641 \u062a\u0648\u0627\u0632\u0646 \u0647\u0627\u0631\u062f\u064a \u0648\u0627\u064a\u0646\u0628\u0631\u063a \u0639\u0646 \u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u063a\u064a\u0631 \u0645\u0647\u0645\u0629 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0644\u0644\u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 NLRP3 \u0641\u064a rs10925024 \u0648 rs4612666 \u0648 rs34777555 \u0648 rs10754557 . 35 SNPs \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648 10 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629 \u0644\u0640 rs10925024 \u0643\u0627\u0646 \u0644\u062f\u064a\u0647\u0645 \u0641\u0631\u0648\u0642 \u0630\u0627\u062a \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 NLRP3 SNPs \u0627\u0644\u0623\u062e\u0631\u0649 \u0644\u0645 \u062a\u0643\u0646 \u0643\u0630\u0644\u0643. \u064a\u0631\u062a\u0628\u0637 CAL \u0648 NLRP3 rs10925024 \u0623\u064a\u0636\u064b\u0627 \u0628\u0634\u0643\u0644 \u0625\u064a\u062c\u0627\u0628\u064a \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646. \u0643\u0627\u0646\u062a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0641\u0631\u062f\u064a\u0629 (OR) \u0644\u0640 IKK\u03b2 SNPs \u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 5.264 \u0644\u0640 rs17875746 \u0648 0.900 \u0644\u0640 rs12676482. .\u0627\u0631\u062a\u0628\u0637 rs17875746 allele-T \u0628\u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 (OR = 6.750) \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643 \u060c \u0647\u0646\u0627\u0643 \u0627\u0631\u062a\u0628\u0627\u0637 \u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0640 rs17875746 \u0645\u0639 \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u060c CAL \u0648 GR. \u0632\u0627\u062f\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0644\u0639\u0627\u0628 TNF-\u03b1 \u0648 Caspase-1 \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648\u062a\u0631\u062a\u0628\u0637 \u0628\u0634\u0643\u0644 \u0625\u064a\u062c\u0627\u0628\u064a \u0645\u0639 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0628\u0639\u0636\u0647\u0627 \u0627\u0644\u0628\u0639\u0636. \u0644\u0644\u062a\u0645\u064a\u064a\u0632 \u0628\u064a\u0646 \u0635\u062d\u0629 \u0627\u0644\u0644\u062b\u0629 \u0648\u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u060c \u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0646\u0637\u0642\u0629 \u0627\u0644\u0648\u0627\u0642\u0639\u0629 \u062a\u062d\u062a \u0645\u0646\u062d\u0646\u0649 TNF-\u03b1 \u0648 Caspase-1( 0.978 \u0648 0.998)\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646\u062a \u0646\u0642\u0627\u0637 \u0627\u0644\u0641\u0635\u0644 \u0627\u0644\u0645\u0642\u062a\u0631\u062d\u0629 128.163 \u0648 1.626 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/span>
\n\u0627\u0647\u0645 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0648\u0635\u0644\u062a \u0627\u0644\u064a\u0647\u0627 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0646 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 NLRP3 \u0648 IKK\u03b2 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643 \u060c \u0623\u0638\u0647\u0631 caspase-1 \u0648 TNF-\u03b1 \u062d\u0633\u0627\u0633\u064a\u0629 \u0648\u062e\u0635\u0648\u0635\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0648\u062a\u0645\u064a\u064a\u0632\u0645\u0631\u0636 \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0639\u0646 \u0635\u062d\u0629 \u0627\u0644\u0644\u062b\u0629. \u0623\u062e\u064a\u0631\u064b\u0627 \u060c \u064a\u0631\u062a\u0628\u0637 NLRP3 rs10925024 \u0648 IKK\u03b2 rs17875746 \u0628\u0634\u0643\u0644 \u0625\u064a\u062c\u0627\u0628\u064a \u0645\u0639 TNF-\u03b1 \u0648 caspase-1 \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0639\u0631\u0627\u0642\u064a\u064a\u0646 \u0627\u0644\u0639\u0631\u0628 \u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u062a\u0641\u0627\u0639\u0644 \u062a\u0622\u0632\u0631\u064a. <\/span>
\n\u0648\u062a\u0645 \u0642\u0628\u0648\u0644 \u0627\u0644\u0627\u0637\u0631\u0648\u062d\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0629 .<\/span><\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u062a\u0628\u062d\u062b \u062d\u0648\u0644 \u062a\u0642\u064a\u064a\u0645 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 \u0627\u0644\u0633\u0646 \u0648\u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0645\u0627 \u0628\u0645\u0633\u062a\u0648\u0649 … 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\u0627\u0644\u0644\u0639\u0627\u0628 Caspase-1 \u0648TNF-\u03b1 - \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0623\u0633\u0646\u0627\u0646- \u062c\u0627\u0645\u0639\u0629 \u0628\u063a\u062f\u0627\u062f<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/codental.uobaghdad.edu.iq\/?p=35408\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u0627\u0637\u0631\u0648\u062d\u0629 \u0641\u064a \u0643\u0644\u064a\u0629 \u0637\u0628 \u0627\u0644\u0623\u0633\u0646\u0627\u0646 \u062a\u0628\u062d\u062b \u062d\u0648\u0644 \u062a\u0642\u064a\u064a\u0645 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062c\u064a\u0646\u064a NLRP3 \u0648 IKK\u03b2 \u0641\u064a \u0627\u0644\u062a\u0647\u0627\u0628 \u062f\u0648\u0627\u0639\u0645 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